University of Hyderabad Scientist and his team
discover New Tools to Study Unstable
For the first time king size
pre-transition state of asymmetric supramolecular reaction was discovered
and analyzed by Dr. D. B. Ramachary and his team from Catalysis
Laboratory, School of Chemistry, University of Hyderabad. The findings
have been published in the prestigious international chemistry journal,
Chemistry - A European Journal, published by Wiley-VCH on behalf of
Entire living and non-living systems existed in this world are generated
through variety of chemical and biological reactions on the simple
atoms/molecules as starting materials catalyzed by small amino acids to
To understand the process of chemical and biological reactions in living
and non-living systems, first we need to understand the catalytic power of
small to big molecules in a variety of chemical and biological reactions.
That is the reason for many chemists/biologists to study and practice the
catalysis as an important area in chemical and biological sciences.
For the last few decades, many chemists/biologists are working to reveal
the reaction pathways in a clearer manner especially on the “transition
state” of the reactions.
In 1999, Professor Ahmed H. Zewail from California Institute of
Technology, Pasadena, USA got Nobel Prize in Chemistry for his studies of
the transition states of fundamental chemical reactions using ultra-short
laser flashes, on the time scale on which the reactions actually occur (femtosecond
spectroscopy). Professor Zewail's contributions have brought about a
revolution in chemistry and adjacent sciences, since this type of
investigation allows us to understand and predict important reactions.
But this femtosecond spectroscopy may not be suitable to study the
transition states of sensitive asymmetric reactions due to the use of high
energy ultra-short laser flashes.
Alternatively Dr. D. B. Ramachary from School of Chemistry, University of
Hyderabad emphasizes the need for development of different smooth ways of
studying pre- or post-transition states of complex asymmetric chemical
reactions using electrospray ionization with high resolution mass
spectrometry (ESI-HRMS) technique that have an influence on the variety of
“Highly reactive pre-transition state of the chemical reactions can be
made much more stable to monitor with ESI-HRMS by designing the processes
in such a way that multiple weak hydrogen bond and covalent bond
interactions operate synergistically between substrates and catalysts in
the course of reaction,” he said.
Dr. D. B. Ramachary, Ms. R. Sakthidevi and Ms. K. S. Shruthi for the first
time discovered the utilization of large size supramolecular rings in the
pre-transition state of enamine-based Michael reactions for the high
asymmetric induction. They have got a strong support for the hypothesis
which involves a stable pre-transition state supramolecular assembly
through careful investigation of the Michael reaction of cyclohexanone and
2-(2-nitrovinyl)phenol under the d-proline/quinine-NH-thiourea-catalysis
using electrospray ionization with high resolution mass spectrometry (ESI-HRMS)
technique, which enabled them to identify all critical proposed catalytic
intermediates (see Scheme).
Enantiomerically pure, drug-like hexahydroxanthenes having three
contiguous stereocenters were synthesized through supramolecular-catalysis
by D-proline and quinine-NH-thiourea followed by reductive etherification
from simple precursors under the mild conditions (see Scheme).
Dr Ramachary said he derived the inspiration to develop this novel
chemical philosophy/technology from the sociological chemistry, where
people work together to sustain their identity and success.
“Similarly, design of synergetic one-pot combination of multiple-hydrogen
bond interactions and multiple-covalent bonds between substrates and
catalysts will be victorious over many problems in organic and
pharmaceutical chemistry,” he said.
site is conceived, designed, and maintained by
All rights reserved
world wide. Copyright © 1999- 2012. Mail your queries to
Neither Reachout Business Network, nor the sources it obtained the
information from, are responsible for the correctness/validity of the
information in these pages. It is a collection of both facts and opinions. You
are advised to verify all information with a reliable source before acting on
it. This disclaimer applies to all pages of ReachoutHyderabad.com.Reproduction
in whole or in part in any form or medium without written permission of